Posts Tagged ‘sleep’

Sleep as Infection Fighting

November 19, 2015

More and more I see the body’s biological fight of infection as a major cause of many of our human problems, problems that are too often blamed on social relationships etc. We blame the people out there, but the greater danger – and our body is responding to it if we are unconscious of it – is infection.

Our conscious mind is not much in the fight, but the other parts of our nervous system seem to be making infection fighting, job one in importance. When we recognize that, I think it will solve a lot of our trauma.

Then I’ll take this one step further and say that sleep is mostly for fighting infection while resetting the digestive system. Wake and nurture, Sleep and fight infection.

Block Those Bad Bugs

Sleep idea Updates

February 3, 2015

Why do we sleep? My latest suggestion is that NREM is glymph cleaning for mostly the cerebrum, our top brain. And during this sleep time, most cerebrum activities are reduced. And REM is glymph cleaning for mostly the brain stem, limbic system, and perhaps the cerebellum – the other parts of the brain. And during these sleep periods most of the activities connected to those parts of the brain are reduced or altered. Many facts seem to fit, and it can be tested to see if it is valid.

Muscle atonia during REM sleep.
Some suggest that we are paralyzed with muscle atonia in REM sleep to make sure we don’t act out our nightmares. I think it is just the opposite. Muscle atonia causes the nightmares.
REM sleep is one part of the nightly glymphatic cleanse of the brain (perhaps mostly the parts of the brain not including the cerebrtum). During that period the part of the brain that controls muscles seems to be ‘out for cleansing’ and that part of the body is paralyzed.
The nightmares may be just a reflection of that paralysis. The nightmares put into visual pictures the bodies shut down during REM sleep, of muscles due to the brain ‘closed’ for cleaning.:”
During this time body temperature approaches that of the environment. That may be because muscle atonia has stopped the muscles from producing body heat that comes from muscle movement -70% of body heat.

Sleep and Chronic Pain

June 26, 2014

Why do we sleep? Why do we have chronic pain?

Suggestion that sleep is to cleanse all the areas of the body that have blood barriers.
Suggestion that without sleep, chronic pain develops in these blood barrier areas.

Sleep may be key for reducing pain. Sleep may be to cleanse those areas outside of the blood stream, or blood barriers.

There is a study that shows that during sleep the blood brain area is cleared through the glymphatic system (see below) . I suggest that this extends to the other blood barrier areas in the body too and that is why we sleep.

blood brain barrier (headaches)
blood spine barrier (back problems)
blood eye barrier (eye strain)
blood ear barrier (ear aches)
blood joint barriers (joint pain)
blood germ cell areas (sexual dysfunction)

Suggestion that the body, during sleep, works from head down and repeats the process 4 or 5 times a night – 4 or 5 cycles of NREM then REM.

NREM (80% of the time) active glymphatic system in blood barriers in brain, eyes, ears, (head area)
REM (20% of the time) active glymphatic system in blood barriers in spine, germ cells, joints. (body area)

BRAIN – BLOOD BRAIN BARRIER
SPINAL CORD – BLOOD SPINAL CHORD BARRIER
EYES – BLOOD RETINAL BARRIER
INNER EAR – BLOOD LABYRINTH BARRIER
PERIPHERAL NERVOUS SYSTEM – BLOOD NERVE BARRIER
JOINTS – BLOOD SYNOVIAL BARRIER
TESTIS – BLOOD TESTIS BARRIER

Report on Glymphatic system, brain, and sleep.
http://www.sciencedaily.com/releases/2012/08/120815142042.htm

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These posts are built on the premise of the evolution of catabolic and anabolic processes to other separate deconstructive and constructive processes.
Catabolic and anabolic processes evolve but they do not blend
http://wp.me/p5S9X-eO (bio summary)

 

Suggestion that Two Parts of Sleep correlate to Glymphatic Cleaning and Flush of Toxins

June 7, 2014

Suggestion that Two Parts Sleep NREM/REM correlate to Glymphatic Cleaning and Flush of Toxins of Brain and Blood Brain Areas

Figure out why we sleep and that will answer many questions. But why we sleep is very tough to answer.
Taking the glymphatic cleaning idea (see link below) further.

1. Why in sleep?
Quote (Q): One of the clues hinting that the glymphatic system may be more active during sleep was the fact that the amount of energy consumed by the brain does not decrease dramatically while we sleep. Because pumping CSF demands a great deal of energy, researchers speculated that the process of cleaning may not be compatible with the functions the brain must perform when we are awake and actively processing information. AND
Q. Through a series of experiments in mice, the researchers observed that the glymphatic system was almost 10-fold more active during sleep and that the sleeping brain removed significantly more amyloid-beta.

2. Could this go beyond the area of the blood brain/spine barrier to other blood barriers (testis, eyes, ears, joints). Therefore sleep centers on blood barrier areas, while the lymphatic system does the rest. Then the question is – is that enough reason for 8 hours sleep!

Q. The system responsible for disposing cellular waste in the rest of the body, the lymphatic system, does not extend to the brain. This is because the brain maintains its own closed “ecosystem” and is protected by a complex system molecular gateways – called the blood-brain barrier – that tightly control what enters and exits the brain.

3. This seems like a two part process. 1. After the brain cells shrink 60 % cerebral spinal fluid is pumped through the brain’s tissue, then 2. the waste is flushed back into the circulatory system where it enters the blood circulation system and goes to the liver.

Q. Another startling finding was that the cells in the brain “shrink” by 60 percent during sleep. This contraction creates more space between the cells and allows CSF to wash more freely through the brain tissue. In contrast, when awake the brain’s cells are closer together, restricting the flow of CSF. AND
Q. Using these techniques, researchers were able to observe in mice – whose brains are remarkably similar to humans – what amounts to a plumbing system that piggybacks on the brain’s blood vessels and pumps cerebral spinal fluid (CSF) through the brain’s tissue, flushing waste back into the circulatory system where it eventually makes its way to the general blood circulation system and, ultimately, the liver.

4. Could this two part process 1. cleaning the brain (and all blood barrier areas). 2. flushing the toxins;  relate to the two stages of sleep: NREM (80% sleep) and REM (20% sleep) such that
NREM – 80% – cleaning the brain (and other blood barrier areas)
REM – 20% – flushing waste back into the circulatory system and to the liver.

Finding the answer to why we sleep will open all kinds of doors to our health and well being, and our understanding of many aspects of our life

http://www.urmc.rochester.edu/news/story/index.cfm?id=3956

Final Quote:. The pathway consists of a para-arterial influx route for cerebrospinal fluid (CSF) to enter the brain parenchyma, coupled to a clearance mechanism for the removal of interstitial fluid (ISF) and extracellular solutes from the interstitial compartments of the brain and spinal cord. Exchange of solutes between the CSF and the ISF is driven by arterial pulsation and regulated during sleep by the expansion and contraction of brain extracellular space.

Sleep caused by the Small Intestines (Jejunum) not the Pineal Gland?

September 15, 2013

Whoa! it’s believe it or not time – this has to do with the jejunum.
Seems it may be the source of both SLEEP, and fear reflex VOMITING.

Book on sleep Principles and Practice of Sleep Medicine Chapter 27 (online)

These thoughts raise the issue of whether there may be changes in the GI system with food ingestion that could produce a hypnotic effect. Along these lines, an intriguing observation was made by Alverez[73] in 1920. He noted that distention of a jejunal balloon caused his human subject to drop off to sleep. The hypnotic effects of afferent intestinal stimulation have also been documented in animal studies. Perhaps the most notable work was a study which induced cortical synchronization in cats by both mechanical and electrical stimulation of the small bowel.[74]

73. Alverez WC: Physiologic studies on the motor activities of the stomach and bowel in man. Am J Physiol 1920; 88:658-660.
74. Kukorelli T, Juhasz G: Sleep induced by intestinal stimulation in cats. Physiol Behav 1976; 19:355-358.

This too from wikipedia: If the jejunum is impacted by blunt force the emesis reflex (vomiting) will be initiated.

Finally most of the melatonin comes from, not your head but your gastrointestinal tract. Melatonin is a hormone that induces sleep.
Levels of melatonin rise as the body temperature falls, to encourage feelings of sleepiness. The opposite occurs to wake us up.

“The concentration of melatonin in the gastrointestinal tissues surpasses blood levels by 10–100 times and there is at least 400× more melatonin in the gastrointestinal tract than in the pineal gland.”

 


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