Biological Ideas – Speculation Over the Years

Reader, these very speculative, biological ideas are my own as far as I know. Time will tell which if any will be proven correct.

1. Life can be defined as the most stable chemical response to the Sun cycle, specifically the Sun/UV/hot then night/cool daily cycle at the time of life’s origin.
2. Catabolic and anabolic chemical processes evolved but did not blend.
3. There is a direction in evolution toward better catabolic and anabolic processes.
4. When there is a mutation on either catabolic or anabolic processes, there is selection pressure on the other to match the good mutation, or mitigate the bad one.
5. Catabolic and anabolic processes started as a reflection of the day night, Sun cycle:
Catabolic – day – dry – hydrophobic. // Anabolic – night – wet – hydrophilic.
6. During the origin of life, there was different selection pressure on each set of bases due to the fact that A-T pairing has 2 hydrogen bonds and C-G pairing has 3 hydrogen bonds. There is quicker denaturing in higher heat in A-T bonds (more activity in heat), then in G-C bonds (more stability in heat).
7. The reason for 3 bases in a codon is because the middle base pair is better protected.
8. Selection Pressure Model:
The greater the selection pressure – directional or diversifying selection – the greater the speed of evolution in the area of the selection pressure, AND
the lower the selection pressure – stabilizing selection – the lower the speed of evolution in the area of the selected pressure. Or nothing changes until it’s forced to.
9. Four Directions in Life Processes: a. take in good, b. block out bad. c. hold in good. d. excrete out bad.
10. SETI should consider looking for alien life in the electromagnetic spectrum at 260 nm instead of just the ‘water hole’.  DNA bases have an average UV absorbance maximum around 260 nm.

1. The idea that REM sleep is for refreshing the mind. and NREM sleep for refreshing the body seems the most likely for why we sleep.
Part of the reason for REM sleep may be that it is sleep for one or both hemispheres of the R-complex brain.
Part of the reason for NREM sleep may be that it is sleep for one or both hemispheres of the neo-cortex
2. Breast feeding sets up the digestion system of food in and waste out and should be continued for longer than 6 months. It is vital for the well being of the infant.
3. Weaning is a major biological event in the infants life, and it sets up how that child will process liquids and solids that are not breast milk, and excrete out wastes.
4. Separation anxiety may be the reflection of the biological loss of breast milk in the infant. Stranger anxiety may be the reflection of the biological change from breast milk to ‘stranger’ foods and liquids. Separation anxiety seems to be directly related to Freud’s oral stage.
5. Stranger anxiety, or fear of new foods, new places, people, etc. is a reflection of the biological fear of infection from food and water in the R-complex brain. Excess fat seems to be treated in the same way as infection and causes more trauma. Stranger anxiety seems to be directly related to Freud’s anal stage.
6. Conglomerate brain idea. The nervous system is a composite of different nervous systems. The basic division is that into visceral (ENS and R-Complex) and somatic (Neocortex). My suggestion is for these 3 main ones:
the ENS or enteric nervous system or gut brain, that controls food in and waste out., the R-complex, that controls inside body processes and the neocortex that controls the senses, and higher thinking processes.
7. These 3 nervous systems seem to have evolved from the inside out. First the digestive tract, (ENS) then the brain for circulating and regulating those nutrients, temperature control, and other inner body processes, and perhaps movement (R-complex), and finally the head brain for sense perception and higher thinking (Neo-Cortex).
8. The different parts of the nervous system may work somewhat independently. During times of trauma, or when past trauma is triggered through memory, there may be conscious or repressed trauma between the somewhat independent and separate parts of the conglomerate brain. This may lead to auto immune type problems.
9. Most immune processes are in NREM sleep and deal with the R-complex brain. The biggest biological threat to humans is pathogens from the alimentary tract.
10. Memory may have evolved from adaptive immunity.
11. Teen rebellion, and trauma is most likely a response to the biological changes from puberty.
13. Replication may have begun as an evolved waste out strategy. Dividing a cell in half not only allows the cell’s genes to continue in the daughter cell, but it allows the father cell, now half as large, to continue to grow .
14. Liver circadian rhythm may be a key clue to understanding why we sleep. The liver switches at night from bile production for fat digestion, to synthesizing chemicals and processing toxins. This may be a major clue to the biological changes in sleep.
1. There is a danger of human selection that restricts what species exist to only those that support humans. This is short sighted and reduces needed diversity.
2. The reason for our sweet tooth may be connected to the fact that sugar not only brings quick energy, but it is the easiest and fastest food to digest.
3. The colon is important as a water tank to supplement the water needed for the next day’s digestion. Feces acts like a sponge to hold in needed water. It also holds in the good gut bacteria.
4. Life can also be catalogued by a. dividing all processes into either catabolic or anabolic processes or b. dividing all processes into visceral or somatic.
5. There are reasons why scenarios for the origin of life that depend on “X’ Steps of a chemical wand, most likely will not work.
6. Genetic coding was first for ” Double Stability”. That is stability that keeps what works, and adjusts what needs work in that environment. That is the main reason for coding.
7. (add on) Sleep, besides resetting our digestive system, may be to allow the glymphatic system to cleanse all the cells in different parts of the brain – such that NREM sleep (80%) is for the cerebrum (thinking and senses) , and REM sleep (20%) is for the brain stem, limbic system and cerebellum (inside body processes).

Tom Hendricks

5 Responses to “Biological Ideas – Speculation Over the Years”

  1. musea Says:

    Sleep may be to allow the glymphatic system to cleanse all the cells in areas of the body with blood barriers – such that NREM sleep is for the head, ears, and eyes, and REM sleep is for the spine, joints and germ cells.

  2. musea Says:

    Life is 99% likely to start = most likely scenario

    Life, the origin of life, is more likely to start if it had a 99% chance of starting; than if it had a 1% of starting. So most likely the OOL was 99% likely, not 1%
    (or 90%, not 10%, or 70% not 30%, etc.)

    For me the turning point to the study of the OOL, is that life is not a fluke, but the most stable chemical reaction to the environment
    Though this proves nothing, it may adjust the mindset in OOL investigation, that seems stuck in a rut.

  3. musea Says:

    Johnjoe McFadden (letter to the author – excerpt)

    Your book was a fascinating read. You had one line that touched on some of my ideas about the origin of life,
    when you said we should look for some type of mechanism…

    I suggest that mechanism was simply stability:
    That chemical system that was the most stable in that environment, and could last through each day, was life.

    When I look at the origin as stability – stable in keeping what works, and changing what doesn’t – then the rest seemed to fall into place.

  4. musea Says:

    Two problems with most origin of life scenarios:
    1. Life magically pops up completely formed.
    2. Life magically survives a hostile environment without any evolved protection.

  5. musea Says:

    Which absorbs light more strongly, folded or unfolded nucleic acids, answer unfolded.
    So FOLDED nucleic acids protects better against UV.

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